Yes. There are a number of things that can be done to improve this situation in the short-term. There are ways to try to keep it from happening in the future, too. For short-term improvement:

• Close other applications that are open and not being used.
• Merge layers that are no longer needed to be separate.
• Clear the undo information if you don't need to undo any current steps. Use the menu Control > Clear Stored Undo Steps.
• Move to a new page and return to your current page.
• Use a smaller brush size.
• Exit from TwistedBrush and start it back up if you are still having problems.

If you continually run low on memory while using TwistedBrush, you can:

• Purchase more memory for your computer.
• Work on smaller page sizes in TwistedBrush.
• Set the Max Undo Levels to a smaller number through the menu Edit > Preferences.

Alternatively if you are running Windows XP or Vista (32 bit Editions) there is a system level setting within Windows to allow for applications to have access to more memory. The switch is called 3GB and will allow TwistedBrush versions 16.01 and later access to 3GB or memory instead of the standard 2GB. Search the microsoft support forums on the internet for information on setting this switch for your version of Windows.

If you still need access to more memory you can install TwistedBrush on Windows (XP, Vista or 7) 64 bit editions and this will give TwistedBrush up to 4GB of memory in TwistedBrush versions 16.01 and later.